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Pancreatitis-Autoimmune Condition

Pancreatitis-Autoimmune Condition

Some serious illnesses can have a significantly adverse impact on the digestive tract and its interrelated organs. One such disorder is the pancreatitis-autoimmune condition.

Brief Overview of The Pancreas

The pancreas is a small but flat gland situated deep inside your abdominal region. One part of the organ lays between your stomach and spine. Another part of this vital system is hidden behind the upper portion of your small intestine.


Your pancreas carries out two critical functions. One role is producing chemicals called enzymes, which help expedite and regulate the digestive process. Enzymes break down fats, sugars, and starches. Your pancreas also creates hormones – chemical messengers that travel through your blood. The most vital of these chemicals is insulin, which is essential for blood sugar regulation. Besides helping regulate blood sugar levels, pancreatic hormones help control appetite, stimulate stomach acids, and tell your stomach when to empty.

The Disease Process

Pancreatitis-autoimmune condition occurs when the pancreas becomes inflamed and swollen. When the condition is pronounced, you can experience tangible physical indicators and potentially serious illness.


The pancreatitis-autoimmune condition happens when the body’s immune system inexplicably attacks the pancreas. Several noted autoimmune ailments have been thought to bring on pancreatitis, such as:

  • Sjogren’s Syndrome.
  • Rheumatoid arthritis.
  • Primary biliary cirrhosis.
  • Lupus.
  • Primary sclerosis cholangitis, sometimes abbreviated as PSC.
  • Sarcoidosis.

Researchers think that the autoimmune form of the disease is highly unusual and strikes far fewer individuals than the disorder caused by more typical causes, including:

  • Alcohol abuse.
  • Ingesting excessive amounts of alcohol and prescription drugs together.
  • Gallstones.
  • Elevated cholesterol levels.
  • Abdominal injury.
  • Various infections.
  • Obesity
  • Pancreatic cancer.

Types of Pancreatitis-Autoimmune Condition

There are two types of pancreatitis-autoimmune condition.

Type One

The illness’s first category not only impacts the pancreas but other bodily components, such as your salivary glands, kidneys, liver, lymph nodes, and bile ducts. Moreover, this differentiation often mimics pancreatic cancer.

Type Two

Typically, the second type of the disease only impacts the pancreas. Studies have concluded that a considerable percentage of those diagnosed with inflammatory bowel disease (IBD) stand at a higher risk of affliction.

Risk Factors

Risk factors differ depending upon the specific type of pancreatitis-autoimmune condition.

Your chances of developing Type One increase if you are over age 60 and male. Being over age 40 and having a preexisting case of inflammatory bowel disease elevates your risk of contracting the second variation. Type Two cases are distributed equally among men and women.

Physical Manifestations

In its early stages, the condition does not always produce noticeable symptoms. When symptoms do occur, you might experience:

  • Abdominal pain.
  • Unexplained or unintended weight loss.
  • Benign masses or growths inside the pancreas.
  • Back pain.
  • Tiredness.
  • Digestive symptoms like appetite loss, nausea, and vomiting.
  • Dark urine.
  • Pale stools.
  • Yellowing skin or eyes, which is medically called jaundice.

Note that some cases do not produce any significant symptoms.

Potential Complications

In advanced stages, the pancreatitis-autoimmune condition can result in complications, such as the onset of diabetes, a narrowing of the pancreas and surrounding bile ducts, and the development of calcium-laden stones inside your pancreas.

The condition has been linked to a digestive problem called pancreatic exocrine insufficiency. Pancreatic inflammation can hinder the organ’s capacity to produce digestive enzymes, resulting in symptoms like diarrhea, nutritional deficiencies, unexplained weight loss, and bone mineral absorption problems.


The pancreas’s location often means associated illnesses do not always produce real symptoms until they have reached a moderate to an advanced stage. A diagnosis is critical even for asymptomatic persons holding one or more risk factors. A firm diagnosis is crucial to rule out cancer and other serious ailments.

Specific simple blood tests can reveal the presence of chemicals often associated with the condition. Your doctor can typically use internal imaging tools like ultrasound or computerized axial tomography (CAT scans) to confirm the diagnosis.

You may need a pancreatic biopsy. During this procedure, a tiny portion of the gland is removed and taken to a laboratory for in-depth examination under a microscope. Usually, biopsies are performed to rule out malignancies.

Treatment Options

Your doctor will weigh several factors before determining the best course of treatment. Such issues include your:

  • Age.
  • Overall health.
  • The disorder’s specific type.
  • How far advanced the disease process is.

Standard therapeutic protocols include administering immune system-suppressing drugs, steroids, and biliary stenting, which is performed to drain obstructed bile ducts.

Should you be diagnosed with the Type One variation, your doctor will also likely monitor other potential at-risk organs to prevent the disease from spreading and developing other problematic, possibly significant complications.


Usually, a pancreatitis-autoimmune condition is not life-limiting, and patients enjoy a favorable prognosis. It must be officially diagnosed and properly addressed.

Contact Us

Though capable of producing alarming and potentially debilitating symptoms, pancreatitis precipitated by immune system issues is often controllable.

Our practice began more than 15 years ago and has emerged as one of the leading gastroenterology practices in central Florida. We perform a host of diagnostic procedures using state-of-the-art equipment in a friendly, comfortable, and inviting atmosphere where patient care is always a top priority. Contact us today!

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